Black cumin:Black Fennel: An Ancient Super Herb With Modern Health Benefits

Black cumin Black Fennel: An Ancient Super Herb With Modern Health Benefits

Black cumin
Black cumin

In a recent review published in the journal Biomedicine, researchers discussed the potential of Nigella Sativa as a medicinal agent.

Nickel Sativa: Distribution and Plant Constituents

Nigella sativa, also known as black seed or black cumin, is a member of the Ranunculus family. The fruit of the Nigella sativa plant consists of three to six carpels, each containing seeds that turn black when ripe.

India’s exporting countries are Brazil, Colombia, Malaysia and Canada. Apart from India, Nigella sativa grows in Egypt, Greece, Saudi Arabia, Iran and Pakistan.

The main biological components of Nigella Sativa are derived from its stems, followed by its outer leaves and roots. Various chemical classes of primary and secondary metabolites such as alkaloids, terpenes, terpenoids, phytosterols, flavonoids, phenolic acids, tannins have been identified in Swallowtail Sativa.

Major alkaloids such as nigella amine and polyphenols such as quercetrivi and kaempferol have been identified in Nigella sativa. Several fatty acids have been isolated from black germ, including oleic, linoleic and palmitic acids.

Black cumin
Black cumin

The medicinal properties of Nigella sativa are due to the presence of quinine constituents including 4-terpineol, thymohydroquinone (THQ), p-cyme, sesquiterpene, thymol, carvacrol, aholt, especially thymoquinone (TQ) and its derivatives.

Medicinal benefits of black cumin

Black cumin is used in traditional Chinese medicine, Arabic medicine, and Ayurveda. In Arabic medicine, it is used to treat asthma, bronchitis, indigestion, dysmenorrhea, amenorrhea, and skin infections. In comparison, Chinese medicine uses Nigella sativa as an ingredient in formulations to treat headaches.

The oil extracted from the leaves of Nigella Sativa has antioxidant, anti-inflammatory, immunomodulatory, antibacterial properties. Black seeds contain tocopherols, which have strong antioxidant effects, preventing lipid peroxidation at the biological level.

Black cumin is considered a natural cholesterol reducing agent. Furthermore, the high levels of sterols in Nigella sativa suggest its potential use in the prevention of cardiovascular disease (CVD). Nigella Sativa is also effective against diabetes, inflammatory conditions and menopause.

Black cumin
Black cumin

Key mechanisms of Nigella Sativa in reducing cardiometabolic diseases

Several mechanisms may contribute to the cardiometabolic role of Nigella sativa. For example, the antioxidant properties of Nigella Sativa can lower blood pressure in hypertensive patients, while the powerful scavenging activity of TQ significantly reduces levels of reactive oxygen species (ROS).

Many cardiometabolic diseases are associated with weight; Therefore, reducing inflammation has a positive effect on these diseases. Nigella sativa inhibits inducible NO synthase and reduces pro-inflammatory cytokine levels by inhibiting the nuclear factor κB (NF-κB) signaling pathway. Nigella Sativa has the ability to inhibit cyclooxygenase 2 (COX-2), an enzyme associated with the production of cellular inflammatory mediators such as prostaglandins (PG).

Nigella sativa also exhibits anti-dyslipidemic properties. For this purpose, black seed extract inhibits the expression of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and increases the expression of low-density lipoprotein receptors, both of which help reduce cholesterol levels. Are connected.

TQ acts as a peroxidase proliferator-activated receptor gamma (PPAR-γ) antagonist to improve insulin resistance and inhibit intestinal α-glucosidase, which reduces glucose absorption. TQ increases the proliferation and integrity of pancreatic β cells, thereby increasing insulin secretion.

Weight loss effects of Nigella Sativa have been reported in several studies. By itself, the gastrointestinal tract reduces food intake, inhibits intestinal glucose absorption, and increases adiponectin levels.

Cardioprotective effects of Nigella sativa strains were demonstrated in isoproterenol-induced myocardial injury in rats. The cardioprotective activity of black liver cells is linked to the reduction of inflammation and oxidative stress.


Nigella sativa seeds are used in many therapeutic strategies. Black

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